The molecular and cellular basis of exostosis formation in hereditary multiple exostoses
نویسندگان
چکیده
منابع مشابه
Spinal Exostosis in a Boy with Multiple Hereditary Exostoses
We report on a 13-year-old boy who presented with multiple hereditary exostosis and had development of back pain, associated with neurological deficits, and was found to have exostoses in the spinal canal. Spine radiograph showed a cauliflower-like abnormality of multiple exostoses of the posterior arch (pedicle) of the thoracic vertebrae (T3-5). Reformatted CT scanning revealed the simultaneou...
متن کاملMechanisms of Exostosis Formation In a Mouse Model of Hereditary Multiple Exostoses
HS in 2 month-old tibial growth plates from WT (AB) and Ext1Ext2 mutants (C-D). Note that staining is much stronger in WT(A) than mutant tissue (C). Background staining in control sections is shown in (B) and (D). gp, growth plate; bm, bone marrow. Bar: 200 μm Mechanisms of Exostosis Formation In a Mouse Model of Hereditary Multiple Exostoses +Huegel J; Mundy C; Koyama E; Yamaguchi Y; Esko J; P...
متن کاملHereditary multiple exostosis.
Hereditary multiple exostosis is an intriguing genetic condition with a clinical impact in the field of orthopaedics, paediatrics and oncology. In this review we highlight the current knowledge about this condition from a clinical and scientific point of view. This gives us more insight into the molecular mechanisms and current models on which therapeutic agents are based. It allows for a multi...
متن کاملHereditary multiple exostoses.
Hereditary multiple exostoses (HME) is a skeletal disorder which primarily affects enchondral bone during growth. It is characterised by multiple exostoses, usually arising in the juxtaepiphyseal region of the long bones. Exostoses that affect "almost every bone in the body" were first mentioned by John Hunter in his Lectures on the principles of surgery in 1786.1 The first family affected by H...
متن کاملBursa formation with scapular osteochondroma in hereditary multiple exostosis.
Osteochondroma is the most common benign bone tumour present multiple hereditary exostosis (HME). Scapular osteochondroma associated with pain and bursitis is rarely reported in literature. Here, we describe a 49-year-old male with the diagnosis of HME who was admitted to the Department of Thoracic Surgery with a painful and rapidly enlarging mass behind the left scapula. Computed tomography an...
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ژورنال
عنوان ژورنال: International Journal of Experimental Pathology
سال: 2009
ISSN: 0959-9673,1365-2613
DOI: 10.1111/j.1365-2613.2009.00654.x